Code : |
3NZJ
PDBj
RCSB PDB
PDBe
|
Title : |
Crystal structure of yeast 20S proteasome in complex with ligand 2a |
Release Data : |
2011-02-16 |
Compound : |
mol_id |
molecule |
chains |
synonym
|
1 |
Proteasome component Y7
|
A,O
|
Macropain subunit Y7, Multicatalytic endopeptidase complex subunit Y7, Proteinase YSCE subunit 7
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
2 |
Proteasome component Y13
|
B,P
|
Macropain subunit Y13, Multicatalytic endopeptidase complex subunit Y13, Proteinase YSCE subunit 13
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
3 |
Proteasome component PRE6
|
C,Q
|
Macropain subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6, Proteinase YSCE subunit PRE6
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
4 |
Proteasome component PUP2
|
D,R
|
Macropain subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2, Proteinase YSCE subunit PUP2
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
5 |
Proteasome component PRE5
|
E,S
|
Macropain subunit PRE5, Multicatalytic endopeptidase complex subunit PRE5, Proteinase YSCE subunit PRE5
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
6 |
Proteasome component C1
|
F,T
|
Macropain subunit C1, Multicatalytic endopeptidase complex subunit C1, Proteinase YSCE subunit 1
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
7 |
Proteasome component C7-alpha
|
G,U
|
Macropain subunit C7-alpha, Multicatalytic endopeptidase complex C7, Proteasome component Y8, Proteinase YSCE subunit 7, SCL1 suppressor protein
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
8 |
Proteasome component PUP1
|
H,V
|
Macropain subunit PUP1, Multicatalytic endopeptidase complex subunit PUP1, Proteinase YSCE subunit PUP1
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
9 |
Proteasome component PUP3
|
I,W
|
Macropain subunit PUP3, Multicatalytic endopeptidase complex subunit PUP3
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
10 |
Proteasome component C11
|
J,X
|
Macropain subunit C11, Multicatalytic endopeptidase complex subunit C11, Proteinase YSCE subunit 11
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
11 |
Proteasome component PRE2
|
K,Y
|
Macropain subunit PRE2, Multicatalytic endopeptidase complex subunit PRE2, Proteinase YSCE subunit PRE2
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
12 |
Proteasome component C5
|
L,Z
|
Multicatalytic endopeptidase complex subunit C5
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
13 |
Proteasome component PRE4
|
M,1
|
Macropain subunit PRE4, Multicatalytic endopeptidase complex subunit PRE4, Proteinase YSCE subunit PRE4
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
synonym
|
14 |
Proteasome component PRE3
|
N,2
|
Macropain subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3, Proteinase YSCE subunit PRE3
|
|
ec: 3.4.25.1
|
mol_id |
molecule |
chains |
|
15 |
TMC-95A mimic ligand 2a
|
3,4
|
|
|
Source : |
mol_id |
organism_scientific |
organism_common
|
|
1 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
2 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
3 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
4 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
5 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
6 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
7 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
8 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
9 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
10 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
11 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
12 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
13 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
organism_common
|
|
14 |
Saccharomyces cerevisiae
(taxid:4932)
|
Brewer's yeast,lager beer yeast,yeast
|
|
mol_id |
organism_scientific |
|
|
15 |
|
|
|
|
synthetic: yes
|
|
Authors : |
Groll, M., Gallastegui, N., Marechal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, M., Vidal, V., Reboud-Ravaux, M. |
Keywords : |
ubiquitin, protein degradation, N-terminal nucleophilic hydrolase, 19S regulatory particle, ubiquitin-tagged substrates, cytosol, nucleus, hydrolase-hydrolase inhibitor complex |
Exp. method : |
X-RAY DIFFRACTION ( 2.40 Å ) |
Citation : |
20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Groll, M.,Gallastegui, N.,Marechal, X.
et al.
(2010)
Chemmedchem
5
: 1701
- 1705
PubMed: 20715286
DOI: 10.1002/cmdc.201000293
|