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Ligands
Code Name Style Show Link
CE1 O-dodecanyl octaethylene glycol
CL Chloride ion
GOL Glycerol
MN Manganese (II) ion
PO4 Phosphate ion
SO4 Sulfate ion
TRP Tryptophan
Non-standard Residues
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Code : 3NUE   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis complexed with tryptophan
Release Data : 2010-07-28
Compound :
mol_id molecule chains synonym
1 Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG A,B DAHP synthetase, phenylalanine-repressible
ec: 2.5.1.54
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
strain: H37RV
gene: RV2178C
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PPROEXHTA
Authors : Parker, E.J., Jameson, G.B., Jiao, W., Webby, C.J., Baker, E.N., Baker, H.M.
Keywords : Mycobacterium tuberculosis, DAH7P synthase, Shikimate pathway, Aromatic biosynthesis, Evolutionary relationships, Transferase, TRP-bound, Augmented TIM-barrel structure
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis

Webby, C.J.,Jiao, W.,Hutton, R.D.  et al.
(2010)  J.Biol.Chem.  285 : 30567 - 30576

PubMed: 20667835
DOI: 10.1074/jbc.M110.111856

Chain : A, B
UniProt : O53512 (AROG_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7- phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate 2.5.1.54 PubMed:16288916
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