Brand  (β version)

PDB ID: 3NK8

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
DMS Dimethyl sulfoxide PoSSuM
JKZ 4-(trifluoromethyl)-1,5,6,7-tetrahydro-2h-cyclopenta[B]pyridin-2-one PoSSuM
Non-standard Residues
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Structure summary

Code : 3NK8   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Trypsin in complex with fluorine-containing fragment
Release Data : 2010-11-10
Compound :
mol_id molecule chains synonym
1 Cationic trypsin A Beta-trypsin, Alpha-trypsin chain 1, Alpha-trypsin chain 2
ec: 3.4.21.4
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Bovine
Authors : Schiering, N., Vulpetti, A., Dalvit, C.
Keywords : beta barrel, chymotrypsin double beta barrel, peptide hydrolase, Calcium binding, pancreas-duodenum, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.15 Å )
Citation :

Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments.

Vulpetti, A.,Schiering, N.,Dalvit, C.
(2010)  Proteins  78 : 3281 - 3291

PubMed: 20886466
DOI: 10.1002/prot.22836

Reaction

Chain : A
UniProt : P00760 (TRY1_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. 3.4.21.4 -
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