Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
ACY Acetic acid
CDQ 6-[(5-chloro-2-oxo-2,3-dihydro-1h-indol-1-yl)methyl]-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid
SO4 Sulfate ion
Code : 3NF8
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Structural basis for a new mechanism of inhibition of HIV integrase identified by fragment screening and structure based design
Release Data : 2011-04-27
Compound :
mol_id molecule chains
1 Integrase A,B
fragment: catalytic domain, residues 50-212
mutation: F185H, C56S, F139D
Source :
mol_id organism_scientific expression_system
1 Human immunodeficiency virus 1  (taxid:11676) Escherichia coli  (taxid:562)
Authors : Peat, T.S., Newman, J., Deadman, J.J., Rhodes, D.
Keywords : integrase, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design

Rhodes, D.I.,Peat, T.S.,Vandegraaff, N.  et al.
(2011)  ANTIVIR.CHEM.CHEMOTHER.  21 : 155 - 168

PubMed: 21602613
DOI: 10.3851/IMP1716

Chain : A, B
UniProt : Q76353 (No found in current UniProtKB/SwissProt)
Reaction : -