Brand  (β version)

PDB ID: 3NBP

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Ligands
Code Name Style Show Link
JGZ 4-(4-{[4-(4-cyano-2,6-dimethylphenoxy)pyrimidin-2-yl]amino}piperidin-1-yl)benzenesulfonamide PoSSuM
MN Manganese (II) ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3NBP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : HIV-1 reverse transcriptase with aminopyrimidine inhibitor 2
Release Data : 2010-08-18
Compound :
mol_id molecule chains synonym
1 Reverse transcriptase/ribonuclease H A HIV-1 RT p66
ec: 2.7.7.49, 2.7.7.7, 3.1.26.13
mol_id molecule chains synonym
2 p51 RT B HIV-1 RT p51
Source :
mol_id organism_scientific organism_common expression_system
1 Human immunodeficiency virus type 1 group M subtype B  (taxid:11706) HIV-1 Escherichia coli  (taxid:562)
strain: isolate HXB2
gene: gag-pol
mol_id organism_scientific organism_common expression_system
2 Human immunodeficiency virus type 1 group M subtype B  (taxid:11706) HIV-1 Escherichia coli  (taxid:562)
strain: isolate HXB2
gene: gag-pol
Authors : Harris, S.F., Villasenor, A.G.
Keywords : HIV, RT, REVERSE TRANSCRIPTASE, TRANSFERASE RNA-DIRECTED DNA POLYMERASE, NUCLEOTIDYLTRANSFERASE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.95 Å )
Citation :

Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.

Kertesz, D.J.,Brotherton-Pleiss, C.,Yang, M.  et al.
(2010)  Bioorg.Med.Chem.Lett.  20 : 4215 - 4218

PubMed: 20538456
DOI: 10.1016/j.bmcl.2010.05.040

Reaction

Chain : B
UniProt : P04585 (POL_HV1H2)
Reaction: EC: Evidence:
Physiological Direction:
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro. 3.4.23.16 PROSITE-ProRule:PRU00275, PubMed:32053707, PubMed:33542150
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Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. 3.1.26.13 UniProtKB:P03366
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3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid. 3.1.13.2 -
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.49 PROSITE- ProRule:PRU00405
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a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) 2.7.7.7 PROSITE- ProRule:PRU00405
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