Het-PDB Navi2 (PDB: 3N8M)

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Ligands
Code	Name		Style	Show	Link
GOL	Glycerol				PoSSuM

Non-standard Residues
Code	Name	Show
PTR	O-phosphotyrosine
9PR	N-methyl-L-prolinamide

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show
6NA	Hexanoic acid

Download interaction data: 3N8M

Code :

3N8M PDBj RCSB PDB PDBe

Header :

PROTEIN BINDING/PEPTIDE

Title :

Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP

Release Data :

2010-12-15

Compound :

mol_id	molecule	chains	synonym
1	Growth factor receptor-bound protein 2	A	Adapter protein GRB2, SH2/SH3 adapter GRB2, Protein Ash
	fragment: Grb2 SH2 domain, residues 55-153

mol_id	molecule	chains
2	PEPTIDE	B

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: GRB2, ASH expression_system_strain: SG13009 expression_system_vector_type: Plasmid expression_system_plasmid: pQE-60

mol_id	organism_scientific
2
	synthetic: yes

Authors :

Whiddon, B.B., Clements, J.H., Martin, S.F.

Keywords :

Grb2 SH2 domain, ligand preorganization, macrocycles, macrocyclic ligands, PROTEIN BINDING-PEPTIDE complex

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions.

Delorbe, J.E.,Clements, J.H.,Whiddon, B.B. et al.
(2010) ACS MED.CHEM.LETT. 1 : 448 - 452

PDB ID: 3N8M