Brand  (β version)

PDB ID: 3N34

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
FNU 6-amino-5-fluorouridine 5'-(dihydrogen phosphate) PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
PGE Triethylene glycol PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Structure summary

Code : 3N34   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP, produced from 5-fluoro-6-azido-UMP
Release Data : 2011-04-06
Compound :
mol_id molecule chains
1 Orotidine 5'-phosphate decarboxylase A,B
ec: 4.1.1.23
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum  (taxid:36329) Escherichia coli  (taxid:469008)
strain: 3D7
gene: gi|9310996, PF10_0225
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a-LIC
Authors : Liu, Y., Kotra, L.P., Pai, E.F.
Keywords : P. falciparum, orotidine 5'-monophosphate decarboxylase, 5-fluoro-6-amino-UMP, 5-fluoro-6-azido-UMP, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.55 Å )
Citation :

Crystal structure of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase complexed with 5-fluoro-6-amino-UMP, produced from 5-fluoro-6-azido-UMP

Liu, Y.,Kotra, L.P.,Pai, E.F.
To be Published 

Reaction

Chain : A, B
UniProt : Q8IJH3 (Q8IJH3_PLAF7)
Reaction: EC: Evidence:
Physiological Direction:
orotidine 5'-phosphate + H(+) = UMP + CO2 4.1.1.23 ARBA:ARBA00049157
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