Het-PDB Navi2 (PDB: 3MY5)

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Ligands
Code	Name	Link
RFZ	5,6-dichloro-1-beta-D-ribofuranosyl-1h-benzimidazole	PoSSuM
FMT	Formic acid	PoSSuM
SGM	Monothioglycerol	PoSSuM

Non-standard Residues
Code	Name	Show
TPO	Phosphothreonine

Glycosylation
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Modification
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Download interaction data: 3MY5

Code :

3MY5 PDBj RCSB PDB PDBe

Header :

TRANSFERASE/PROTEIN BINDING/INHIBITOR

Title :

CDk2/cyclinA in complex with DRB

Release Data :

2010-09-29

Compound :

mol_id	molecule	chains	synonym
1	Cell division protein kinase 2	A,C	p33 protein kinase
	ec: 2.7.11.22

mol_id	molecule	chains	synonym
2	Cyclin-A2	B,D	Cyclin-A
	fragment: UNP residues 169-430

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: CDK2 expression_system_vector_type: plasmid

mol_id	organism_scientific	organism_common	expression_system
2	Bos taurus (taxid:9913)	Bovine	Escherichia coli (taxid:562)
	gene: CCNA2, CCNA expression_system_vector_type: plasmid

Authors :

Baumli, S., Johnson, L.N.

Keywords :

CDK, cyclin, inhibitor, DRB, TRANSFERASE-PROTEIN BINDING-INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.100 Å )

Citation :

Halogen bonds form the basis for selective P-TEFb inhibition by DRB

Baumli, S.,Endicott, J.A.,Johnson, L.N.
(2010) Chem.Biol. 17 : 931 - 936

Chain :

A, C

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.22	PubMed:1396589, PubMed:24670654, PubMed:28216226, PubMed:28666995, PubMed:9030781
	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.22	PubMed:1396589, PubMed:24670654, PubMed:28666995, PubMed:9030781
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:21565702	Binds 2 Mg(2+) ions.

PDB ID: 3MY5