Het-PDB Navi2 (PDB: 3MVR)

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Ligands
Code	Name		Style	Show	Link
HEM	Protoporphyrin ix containing Fe				PoSSuM
CM5	5-cyclohexyl-1-pentyl-beta-D-maltoside				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3MVR

Code :

3MVR PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

Crystal Structure of cytochrome P450 2B4-H226Y in a closed conformation

Release Data :

2010-09-29

Compound :

mol_id	molecule	chains	synonym
1	Cytochrome P450 2B4	A,B	CYPIIB4, Cytochrome P450 isozyme 2, Cytochrome P450 LM2, Cytochrome P450 type B0, Cytochrome P450 type B1
	ec: 1.14.14.1 fragment: CYP2B4dH mutation: E2A, G22K, H23K, P24T, K25S, A26S, H27K, R29K, H226Y

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Oryctolagus cuniculus (taxid:9986)	Rabbit	Escherichia coli (taxid:562)
	gene: CYP2B4 expression_system_strain: TOPP3 expression_system_vector_type: plasmid expression_system_plasmid: pKK

Authors :

Shah, M.B., Stout, C.D., Halpert, J.R.

Keywords :

Ligand free closed conformation, P450, Cytochrome P450 2B4, monooxygenase, oxidoreductase, membrane protein, CYP 2B4.

Exp. method :

X-RAY DIFFRACTION ( 1.76 Å )

Citation :

Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography.

Wilderman, P.R.,Shah, M.B.,Liu, T. et al.
(2010) J.Biol.Chem. 285 : 38602 - 38611

PubMed: 20880847
DOI: 10.1074/jbc.M110.180646

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

Zhao, Y.,White, M.A.,Muralidhara, B.K. et al.
(2006) J.Biol.Chem. 281 : 5973 - 5981

An open conformation of mammalian cytochrome P450 2B4 at 1.6 A resolution.

Scott, E.E.,He, Y.A.,Wester, M.R. et al.
(2003) Proc.Natl.Acad.Sci.USA 100 : 13196 - 13201

Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.

Zhao, Y.,Sun, L.,Muralidhara, B.K. et al.
(2007) Biochemistry 46 : 11559 - 11567

Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1H-imidazole: Ligand-Induced Structural Response through Alpha-Helical Repositioning

Gay, S.C.,Sun, L.,Maekawa, K. et al.
(2009) Biochemistry 48 : 4672 - 4771

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9 {angstrom} resolution: Insight into the range of P450 conformations and coordination of redox partner binding.

Scott, E.E.,White, M.A.,He, Y.A. et al.
(2004) J.Biol.Chem. 279 : 27294 - 27301

Chain :

A, B

UniProt :

P00178 (CP2B4_RABIT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]	1.14.14.1	-
	-	-

PDB ID: 3MVR

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