Het-PDB Navi2 (PDB: 3MTL)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
FEF	(2z,3e)-2,3'-biindole-2',3(1h,1'H)-dione 3-{O-[(3r)-3,4-dihydroxybutyl]oxime}				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 3MTL

Code :

3MTL PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of the PCTAIRE1 kinase in complex with Indirubin E804

Release Data :

2010-06-09

Compound :

mol_id	molecule	chains	synonym
1	Cell division protein kinase 16	A	Serine/threonine-protein kinase PCTAIRE-1, PCTAIRE-motif protein kinase 1
	ec: 2.7.11.22 fragment: residues in UNP 163-478 mutation: S319D

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	expression_system_vector_type: plasmid expression_system_plasmid: pNIC-CH

Authors :

Krojer, T., Sharpe, T.D., Roos, A., Savitsky, P., Amos, A., Ayinampudi, V., Berridge, G., Fedorov, O., Keates, T., Phillips, C., Burgess-Brown, N., Zhang, Y., Pike, A.C.W., Muniz, J., Vollmar, M., Thangaratnarajah, C., Rellos, P., Ugochukwu, E., Filippakopoulos, P., Yue, W., Das, S., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., Knapp, S., Bullock, A., Structural Genomics Consortium (SGC)

Keywords :

PCTAIRE1, kinase, Indirubin, Structural Genomics, Structural Genomics Consortium, SGC, Transferase

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.

Dixon-Clarke, S.E.,Shehata, S.N.,Krojer, T. et al.
(2017) Biochem.J. 474 : 699 - 713

PubMed: 28057719
DOI: 10.1042/BCJ20160941

Chain :

UniProt :

Q00536 (CDK16_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.22	PubMed:22184064, PubMed:22796189, PubMed:22798068
	-	PubMed:22184064, PubMed:22796189, PubMed:22798068
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.22	PubMed:22184064, PubMed:22796189, PubMed:22798068
	-	PubMed:22184064, PubMed:22796189, PubMed:22798068

PDB ID: 3MTL

Hetero Atom Contents

Structure summary

Reaction