Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
22S N-({(2e)-2-[(2-chlorophenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine
Modified Residues
Code Name Link
LLP (2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid
Code : 3MS7
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Glycogen phosphorylase complexed with 2-chlorobenzaldehyde-4-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl) thiosemicarbazone
Release Data : 2011-01-05
Compound :
mol_id molecule chains synonym
1 Glycogen phosphorylase, muscle form A Myophosphorylase
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) European rabbit,Japanese white rabbit,domestic rabbit,rabbits
other_details: Muscle
Authors : Alexacou, K.-M.
Keywords : Glycogenolysis, type 2 diabetes, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors

Alexacou, K.M.,Tenchiu Deleanu, A.C.,Chrysina, E.D.  et al.
(2010)  Bioorg.Med.Chem.  18 : 7911 - 7922

PubMed: 20947361
DOI: 10.1016/j.bmc.2010.09.039

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction : ((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.