Brand  (β version)

PDB ID: 3MS7

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Ligands
Code Name Style Show Link
22S N-({(2e)-2-[(2-chlorophenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine PoSSuM
Non-standard Residues
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LLP (2s)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid
Glycosylation
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Structure summary

Code : 3MS7   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE INHIBITOR
Title : Glycogen phosphorylase complexed with 2-chlorobenzaldehyde-4-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl) thiosemicarbazone
Release Data : 2011-01-05
Compound :
mol_id molecule chains synonym
1 Glycogen phosphorylase, muscle form A Myophosphorylase
ec: 2.4.1.1
Source :
mol_id organism_scientific organism_common
1 Oryctolagus cuniculus  (taxid:9986) European rabbit,Japanese white rabbit,domestic rabbit,rabbits
other_details: Muscle
Authors : Alexacou, K.-M.
Keywords : Glycogenolysis, type 2 diabetes, TRANSFERASE-TRANSFERASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors

Alexacou, K.M.,Tenchiu Deleanu, A.C.,Chrysina, E.D.  et al.
(2010)  Bioorg.Med.Chem.  18 : 7911 - 7922

PubMed: 20947361
DOI: 10.1016/j.bmc.2010.09.039

Reaction

Chain : A
UniProt : P00489 (PYGM_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
[(1->4)-alpha-D-glucosyl](n) + phosphate = [(1->4)-alpha-D- glucosyl](n-1) + alpha-D-glucose 1-phosphate 2.4.1.1 UniProtKB:P11217
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