Brand  (β version)

PDB ID: 3MLA

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Ligands
Code Name Style Show Link
JJZ 4-[2-(anthracen-9-ylmethylidene)hydrazino]-N-(3-chlorophenyl)-4-oxobutanamide PoSSuM
FMT Formic acid PoSSuM
DMS Dimethyl sulfoxide PoSSuM
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Structure summary

Code : 3MLA   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : BaNadD in complex with inhibitor 1_02
Release Data : 2010-07-28
Compound :
mol_id molecule chains synonym
1 nicotinate-nucleotide adenylyltransferase A,B Deamido-NAD(+) pyrophosphorylase, Deamido-NAD(+) diphosphorylase, Nicotinate mononucleotide adenylyltransferase, NaMN adenylyltransferase
ec: 2.7.7.18
Source :
mol_id organism_scientific expression_system
1 Bacillus anthracis  (taxid:1392) Escherichia coli  (taxid:562)
gene: BAMEG_4595, nadD
expression_system_strain: BL21
expression_system_vector_type: plasmid
expression_system_plasmid: PET28a
Authors : Huang, N., Eyobo, Y., Zhang, H.
Keywords : NMNAT-inhibitor complex, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.750 Å )
Citation :

Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.

Huang, N.,Kolhatkar, R.,Eyobo, Y.  et al.
(2010)  J.Med.Chem.  53 : 5229 - 5239

PubMed: 20578699
DOI: 10.1021/jm100377f

Reaction

Chain : A, B
UniProt : C3L5T6 (NADD_BACAC)
Reaction: EC: Evidence:
Physiological Direction:
ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate 2.7.7.18 HAMAP- Rule:MF_00244
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