PDB ID: 3MDV
Hetero Atom Contents
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Structure summary
Code : | 3MDV PDBj RCSB PDB PDBe | ||||||||||||
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Header : | OXIDOREDUCTASE | ||||||||||||
Title : | Clotrimazole complex of Cytochrome P450 46A1 | ||||||||||||
Release Data : | 2010-07-28 | ||||||||||||
Compound : |
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Source : |
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Authors : | Mast, N., Charvet, C., Pikuleva, I., Stout, C.D. | ||||||||||||
Keywords : | CYP46A1, P450 46A1, P450, CLOTRIMAZOLE, MONOOXYGENASE, METABOLIC ENZYME, OXIDOREDUCTASE, HEME, Cholesterol metabolism, Endoplasmic reticulum, Iron, Lipid metabolism, Membrane, Metal-binding, Microsome, NADP, Steroid metabolism, Transmembrane | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.400 Å ) | ||||||||||||
Citation : |
Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
Mast, N.,Charvet, C.,Pikuleva, I.A.
et al.
PubMed: 20667828 Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.
Mast, N.,White, M.A.,Bjorkhem, I.
et al.
PubMed: 18621681 |
Reaction
Chain : | A, B | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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UniProt : | Q9Y6A2 (CP46A_HUMAN) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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