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Ligands
Code Name Style Show Link
PO4 Phosphate ion
MG Magnesium ion
ADP Adenosine-5'-diphosphate
Non-standard Residues
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Glycosylation
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Code : 3MBI   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of the phosphoribosylpyrophosphate (PRPP) synthetase from Thermoplasma volcanium in complex with ADP-Mg2+ and ribose 5-phosphate
Release Data : 2011-04-20
Compound :
mol_id molecule chains synonym
1 Ribose-phosphate pyrophosphokinase A,B,C,D RPPK, Phosphoribosyl pyrophosphate synthase, P-Rib-PP synthase, PRPP synthase
ec: 2.7.6.1
Source :
mol_id organism_scientific expression_system
1 Thermoplasma volcanium  (taxid:50339) Escherichia coli  (taxid:562)
strain: ATCC51530
gene: prs, TV0197, TVG0201915, TVN0197
expression_system_strain: BL21 (DE3) PlysS
expression_system_vector_type: plasmid
expression_system_plasmid: pvp16
Authors : Cherney, L.T., Cherney, M.M., Garen, C.R., James, M.N.G.
Keywords : Phosphoribosyl transferase, ATP analog binding, Ribose 5-phosphate binding, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

The structures of Thermoplasma volcanium phosphoribosyl pyrophosphate synthetase bound to ribose-5-phosphate and ATP analogs.

Cherney, M.M.,Cherney, L.T.,Garen, C.R.  et al.
(2011)  J.Mol.Biol.  413 : 844 - 856

PubMed: 21963988
DOI: 10.1016/j.jmb.2011.09.007

Chain : A, B, C, D
UniProt : Q97CA5 (KPRS_THEVO)
Reaction: EC: Evidence:
Physiological Direction:
ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1- diphosphate + AMP + H(+) 2.7.6.1 HAMAP- Rule:MF_00583
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