Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
01I Naphtho[2,1-B:7,6-B']difuran-2,8-dicarboxylic acid
SO4 Sulfate ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 3MB6   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human CK2 catalytic domain in complex with a difurane derivative inhibitor (CPA)
Release Data : 2010-05-05
Compound :
mol_id molecule chains synonym
1 Casein kinase II subunit alpha A CK II alpha
ec: 2.7.11.1
fragment: UNP residues 1-331
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSNK2A1, CK2A1
Authors : Reiser, J.-B., Prudent, R., Claude, C.
Keywords : kinases, difurane, inhibitor, CK2, ATP-binding, Kinase, Nucleotide-binding, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.75 Å )
Citation :

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

Lopez-Ramos, M.,Prudent, R.,Moucadel, V.  et al.
(2010)  Faseb J.  24 : 3171 - 3185

PubMed: 20400536
DOI: 10.1096/fj.09-143743

Chain : A
UniProt : P68400 (CSK21_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:20545769, PubMed:20625391, PubMed:21482717, PubMed:22184066, PubMed:23123191, PubMed:30699359, PubMed:30898438, PubMed:31439799
left-to-right PubMed:20545769, PubMed:21482717, PubMed:23123191, PubMed:30699359, PubMed:30898438, PubMed:31439799, PubMed:35597237
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:20625391, PubMed:22325354, PubMed:31439799
left-to-right PubMed:31439799