Brand  (β version)

PDB ID: 3MAA

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
FKP Methylpiperazinoforskolin PoSSuM
GSP 5'-guanosine-diphosphate-monothiophosphate PoSSuM
MG Magnesium ion PoSSuM
TAT Adenosine-5'-rp-alpha-thio-triphosphate PoSSuM
Non-standard Residues
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Structure summary

Code : 3MAA   PDBj   RCSB PDB   PDBe
Header : LYASE/LYASE INHIBITOR
Title : Complex of GS-Alpha with the Catalytic Domains of Mammalian Adenylyl Cyclase: Complex with Adenosine 5-O-(L-Thiophosphate) and Low Ca Concentration
Release Data : 2010-04-07
Compound :
mol_id molecule chains synonym
1 Adenylate cyclase type 5 A Adenylate cyclase type V, ATP pyrophosphate-lyase 5, Adenylyl cyclase 5, Ca(2+)-inhibitable adenylyl cyclase
ec: 4.6.1.1
fragment: C1A DOMAIN
mutation: V476M
mol_id molecule chains synonym
2 Adenylate cyclase type 2 B Adenylate cyclase type II, ATP pyrophosphate-lyase 2, Adenylyl cyclase 2
ec: 4.6.1.1
fragment: C2A DOMAIN
mol_id molecule chains synonym
3 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short C Adenylate cyclase-stimulating G alpha protein
Source :
mol_id organism_scientific organism_common expression_system
1 Canis lupus familiaris  (taxid:9615) Dogs Escherichia coli  (taxid:562)
gene: ADCY5, ADENYLYL CYCLASE TYPE V
expression_system_strain: BL-21
expression_system_vector_type: MULTI-COPY PLASMID
expression_system_plasmid: PQE60-H6-VC1(580)
mol_id organism_scientific organism_common expression_system
2 Rattus norvegicus  (taxid:10116) Brown rat,rat,rats Escherichia coli  (taxid:562)
gene: Adcy2, ADENYLYL CYCLASE TYPE II
expression_system_strain: BL-21
expression_system_vector_type: MULTI-COPY PLASMID
expression_system_plasmid: PQE60-ARGC-IIC2
mol_id organism_scientific organism_common expression_system
3 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow Escherichia coli  (taxid:562)
gene: GNAS, GNAS1
expression_system_strain: BL-21
expression_system_vector_type: MULTI-COPY PLASMID
expression_system_plasmid: PQE60-GSALPHA-H6
Authors : Mou, T.-C., Sprang, S.R.
Keywords : ADENYLYL CYCLASE, G(S)ALPHA, ATP-ALPHA-S, CALCIUM ION, LYASE-LYASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Structural basis for inhibition of mammalian adenylyl cyclase by calcium.

Mou, T.C.,Masada, N.,Cooper, D.M.  et al.
(2009)  Biochemistry  48 : 3387 - 3397

PubMed: 19243146
DOI: 10.1021/bi802122k

Reaction

Chain : A
UniProt : P30803 (ADCY5_CANLF)
Reaction: EC: Evidence:
Physiological Direction:
ATP = 3',5'-cyclic AMP + diphosphate 4.6.1.1 PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:1618857, PubMed:16766715, PubMed:19243146, PubMed:8428899
-
Chain : B
UniProt : P26769 (ADCY2_RAT)
Reaction: EC: Evidence:
Physiological Direction:
ATP = 3',5'-cyclic AMP + diphosphate 4.6.1.1 PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:1719547, PubMed:19243146, PubMed:21596131, PubMed:22906005, PubMed:24363043, PubMed:7761832
-
Chain : C
UniProt : P04896 (GNAS2_BOVIN)
Reaction : -