PDB ID: 3MA3
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Structure summary
Code : | 3MA3 PDBj RCSB PDB PDBe | ||||||||||||||||||||||||
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Header : | TRANSFERASE | ||||||||||||||||||||||||
Title : | Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a naphtho-difuran ligand | ||||||||||||||||||||||||
Release Data : | 2010-04-14 | ||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Filippakopoulos, P., Bullock, A., Fedorov, O., Vollmar, M., von Delft, F., Cochet, C., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC) | ||||||||||||||||||||||||
Keywords : | ONCOGENE, KINASE, SERINE-THREONINE, PIM1, STRUCTURAL GENOMICS CONSORTIUM, SGC, ALTERNATIVE INITIATION, ATP-BINDING, MANGANESE, MEMBRANE, METAL-BINDING, NUCLEOTIDE-BINDING, NUCLEUS, PHOSPHOPROTEIN, PROTO-ONCOGENE, SERINE/THREONINE-PROTEIN KINASE, TRANSFERASE, HOST-VIRUS INTERACTION, VIRAL IMMUNOEVASION, VIRION, VIRULENCE, Cell cycle, Cell membrane | ||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.300 Å ) | ||||||||||||||||||||||||
Citation : |
New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.
Lopez-Ramos, M.,Prudent, R.,Moucadel, V.
et al.
PubMed: 20400536 |
Reaction
Chain : | A | ||||||||||||
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UniProt : | P11309 (PIM1_HUMAN) | ||||||||||||
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