Het-PDB Navi2 (PDB: 3M2K)

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Ligands
Code	Name		Style	Show	Link
CEF	Cefotaxime, c3' cleaved, open, bound form				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3M2K

Code :

3M2K PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal Structure of fluorescein-labeled Class A -beta lactamase PenP in complex with cefotaxime

Release Data :

2011-03-16

Compound :

mol_id	molecule	chains	synonym
1	Beta-lactamase	A,B	Penicillinase, Large exopenicillinase, Small exopenicillinase
	ec: 3.5.2.6 fragment: residues 47-301 mutation: E166C

Source :

mol_id	organism_scientific	expression_system
1	Bacillus licheniformis (taxid:1402)	Escherichia coli (taxid:562)
	strain: 749/C gene: penP expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pRSET

Authors :

Zhao, Y.X., Leung, Y.C., Wong, W.T.

Keywords :

beta-lactamase, fluorophore, biosensor, hydrolase, cefotaxime, Antibiotic resistance, Cell membrane, Lipoprotein, Membrane, Palmitate

Exp. method :

X-RAY DIFFRACTION ( 3.50 Å )

Citation :

Structural studies of the mechanism for biosensing antibiotics in a fluorescein-labeled beta-lactamase.

Wong, W.T.,Au, H.W.,Yap, H.K. et al.
(2011) BMC Struct. Biol. 11 : 15 - 15

Chain :

A, B

UniProt :

P00808 (BLAC_BACLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE- ProRule:PRU10101
a beta-lactam + H2O = a substituted beta-amino acid	-	PROSITE- ProRule:PRU10101

PDB ID: 3M2K