Brand  (β version)

PDB ID: 3M1O

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Ligands
Code Name Style Show Link
CJZ 2-[(3,5-dichloro-4-hydroxyphenyl)amino]benzoic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3M1O   PDBj   RCSB PDB   PDBe
Header : HORMONE
Title : Human Transthyretin (TTR) complexed with 2-((3,5-dichloro-4-hydroxyphenyl)amino)benzoic acid
Release Data : 2010-11-17
Compound :
mol_id molecule chains synonym
1 Transthyretin A,B Prealbumin, TBPA, TTR, ATTR
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TTR, PALB
Authors : Kolstoe, S.E., Wood, S.P.
Keywords : AMYLOID, INHIBITOR, AMYLOIDOSIS, DISEASE MUTATION, GAMMA-CARBOXYGLUTAMIC ACID, GLYCOPROTEIN, HORMONE, NEUROPATHY, SECRETED, THYROID HORMONE, TRANSPORT
Exp. method : X-RAY DIFFRACTION ( 1.2 Å )
Citation :

Trapping of palindromic ligands within native transthyretin prevents amyloid formation.

Kolstoe, S.E.,Mangione, P.P.,Bellotti, V.  et al.
(2010)  Proc.Natl.Acad.Sci.USA  107 : 20483 - 20488

PubMed: 21059958
DOI: 10.1073/pnas.1008255107

Reaction

Chain : A, B
UniProt : P02766 (TTHY_HUMAN)
Reaction : -