Brand  (β version)

PDB ID: 3LW0

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Ligands
Code Name Style Show Link
CCX 3-cyano-N-{1-[4-(5-cyano-1h-indol-3-yl)butyl]piperidin-4-yl}-1h-indole-7-carboxamide PoSSuM
Non-standard Residues
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Structure summary

Code : 3LW0   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : IGF-1RK in complex with ligand MSC1609119A-1
Release Data : 2010-09-29
Compound :
mol_id molecule chains synonym
1 Insulin-like growth factor 1 receptor A,B,C,D IGF-1 RECEPTOR KINASE, Insulin-like growth factor I receptor, IGF-I receptor, Insulin-like growth factor 1 receptor alpha chain, Insulin-like growth factor 1 receptor beta chain
ec: 2.7.10.1
fragment: PROTEIN KINASE, UNP residues 983-1286
mutation: E1097A, E1099A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: IGF1R
Authors : Graedler, U., Heinrich, T., Boettcher, H., Blaukat, A., Shutes, A., Askew, B.
Keywords : PROTEIN KINASE, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.79 Å )
Citation :

Allosteric IGF-1R Inhibitors.

Heinrich, T.,Gradler, U.,Bottcher, H.  et al.
(2010)  Acs Med.Chem.Lett.  1 : 199 - 203

PubMed: 24900194
DOI: 10.1021/ml100044h

Reaction

Chain : A, B, C, D
UniProt : P08069 (IGF1R_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:11694888, PubMed:17317169, PubMed:18566589, PubMed:19041240, PubMed:19778024, PubMed:20675137, PubMed:21414779, PubMed:21441024, PubMed:7679099, Ref.54
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