Brand  (β version)

PDB ID: 3LT0

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
FT1 4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 3LT0   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T1
Release Data : 2010-06-16
Compound :
mol_id molecule chains
1 Enoyl-ACP reductase A,B
ec: 1.3.1.9
fragment: residues 96-424
Source :
mol_id organism_scientific expression_system
1 Plasmodium falciparum  (taxid:5833) Escherichia coli  (taxid:562)
gene: FabI
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_plasmid: PET-28a(+)(NOVAGEN)
Authors : Maity, K., Bhargav, S.P., Sankaran, B., Surolia, N., Surolia, A., Suguna, K.
Keywords : Triclosan, Triclosan variant, Enoyl-ACP reductase, oxidoreductase, P.falciparum
Exp. method : X-RAY DIFFRACTION ( 1.96 Å )
Citation :

X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition

Maity, K.,Bhargav, S.P.,Sankaran, B.  et al.
(2010)  Iubmb Life  62 : 467 - 476

PubMed: 20503440
DOI: 10.1002/iub.327

Reaction

Chain : A, B
UniProt : Q9BJJ9 (Q9BJJ9_PLAFA)
Reaction : -