Brand  (β version)

PDB ID: 3LMY

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Ligands
Code Name Style Show Link
CP6 5-(4-chloro-phenyl)-6-ethyl-pyrimidine-2,4-diamine PoSSuM
NDG 2-acetamido-2-deoxy-alpha-D-glucopyranose PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BMA Beta-D-mannopyranose
Modification
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Structure summary

Code : 3LMY   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : The Crystal Structure of beta-hexosaminidase B in complex with Pyrimethamine
Release Data : 2011-02-16
Compound :
mol_id molecule chains synonym
1 Beta-hexosaminidase subunit beta A,B N-acetyl-beta-glucosaminidase subunit beta, Beta-N-acetylhexosaminidase subunit beta, Hexosaminidase subunit B, Cervical cancer proto-oncogene 7 protein, HCC-7
ec: 3.2.1.52
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
other_details: placenta
Authors : Bateman, K.S., Cherney, M.M., Withers, S.G., Mahuran, D.J., Tropak, M., James, M.N.G.
Keywords : 6-stranded anti-parallel beta-sheet, TIM barrel, Disease mutation, Disulfide bond, Gangliosidosis, Glycoprotein, Glycosidase, Hydrolase, Lysosome
Exp. method : X-RAY DIFFRACTION ( 2.80 Å )
Citation :

The Crystal Structure of beta-hexosaminidase B in complex with Pyrimethamine

Bateman, K.S.,Cherney, M.M.,Withers, S.G.  et al.
To be Published 

Reaction

Chain : A, B
UniProt : P07686 (HEXB_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. 3.2.1.52 PubMed:11329289, PubMed:11707436, PubMed:8123671, PubMed:8672428, PubMed:9694901
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H2O + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-3- sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide = a beta-D- 3-sulfogalactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide + N- acetyl-beta-D-galactosamine - PubMed:11707436
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a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetyl-beta-D-galactosamine - PubMed:8123671, PubMed:8672428, PubMed:9694901
left-to-right PubMed:9694901
a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D- galactosamine - PubMed:8123671, PubMed:8672428, PubMed:9694901
left-to-right PubMed:9694901
beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4- sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha- L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D- GalNAc-4-sulfate + N-acetyl-D-galactosamine - PubMed:11707436
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H2O + N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L- iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine = alpha-L-iduronyl- (1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6- sulfogalactosamine - PubMed:11707436
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