Het-PDB Navi2 (PDB: 3LMP)

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Ligands
Code	Name		Style	Show	Link
CEK	(9as)-8-acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-N-(1-naphthylmethyl)-9-oxo-9,9a-dihydrodibenzo[B,D]furan-4-carboxamide				PoSSuM

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Download interaction data: 3LMP

Code :

3LMP PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator

Release Data :

2010-04-14

Compound :

mol_id	molecule	chains	synonym
1	Peroxisome proliferator-activated receptor gamma	A	PPAR-gamma, Nuclear receptor subfamily 1 group C member 3
	fragment: UNP residues 234-505

mol_id	molecule	chains	synonym
2	Peptide of Nuclear receptor coactivator 1	C	NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52, Class E basic helix-loop-helix protein 74, bHLHe74
	fragment: UNP residues 686-700

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: NR1C3, PPARG expression_system_strain: SG13009 expression_system_vector_type: plasmid expression_system_plasmid: pQE30

mol_id	organism_scientific
2
	synthetic: yes other_details: Synthetic peptide

Authors :

Matsui, Y., Hanzawa, H.

Keywords :

three-layered alpha-helical sandwich, Activator, Alternative splicing, Diabetes mellitus, Disease mutation, DNA-binding, Metal-binding, Nucleus, Obesity, Phosphoprotein, Polymorphism, Receptor, Transcription, Transcription regulation, Zinc-finger

Exp. method :

X-RAY DIFFRACTION ( 1.900 Å )

Citation :

Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives

Furukawa, A.,Arita, T.,Satoh, S. et al.
(2010) Bioorg.Med.Chem.Lett. 20 : 2095 - 2098

PubMed: 20219371
DOI: 10.1016/j.bmcl.2010.02.073

Chain :	A
UniProt :	P37231 (PPARG_HUMAN)
Reaction :	-

PDB ID: 3LMP

Hetero Atom Contents

Structure summary

Reaction