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0CE 2-methyl-11-(1-methylethyl)-8-[(2s)-tetrahydro-2h-pyran-2-yl]-2,11,12,13-tetrahydro-4h-indazolo[5,4-a]pyrrolo[3,4-C]carbazol-4-one
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Code : 3L8P   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207
Release Data : 2010-10-06
Compound :
mol_id molecule chains synonym
1 Angiopoietin-1 receptor A Tyrosine-protein kinase receptor TIE-2, hTIE2, Tyrosine-protein kinase receptor TEK, Tunica interna endothelial cell kinase, p140 TEK
ec: 2.7.10.1
fragment: Tie2 fragment 808-1124
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TEK, TIE2
Authors : Fedorov, A.A., Fedorov, E.V., Pauletti, D., Meyer, S.L., Hudkins, R.L., Almo, S.C.
Keywords : receptor tyrosine kinase, cytoplasmic kinase domain, Tie2, inhibitor CEP11207, ATP-binding, Disease mutation, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Receptor, Transferase, Tyrosine-protein kinase
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207

Fedorov, A.A.,Fedorov, E.V.,Pauletti, D.  et al.
To be Published 

Chain : A
UniProt : Q02763 (TIE2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:11513602, PubMed:12609966, PubMed:14665640, PubMed:15851516, PubMed:19223473, PubMed:8382358
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