Brand  (β version)

PDB ID: 3L16

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Ligands
Code Name Style Show Link
JZX 5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-ylthieno[3,2-D]pyrimidin-2-yl)pyridin-2-amine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3L16   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Discovery of (thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer
Release Data : 2010-02-16
Compound :
mol_id molecule chains synonym
1 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform A PI3-kinase p110 subunit gamma, PtdIns-3-kinase subunit p110, PI3Kgamma, PI3K, p120-PI3K
ec: 2.7.1.153
fragment: UNP residues 144-1102
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: PIK3CG
expression_system_common: Fall armyworm
expression_system_strain: Sf9
expression_system_vector_type: plasmid
Authors : Murray, J.M., Wiesmann, C.
Keywords : kinase, ATP-binding, Nucleotide-binding, Transferase, PI3K-gamma p110 gamma
Exp. method : X-RAY DIFFRACTION ( 2.900 Å )
Citation :

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer.

Sutherlin, D.P.,Sampath, D.,Berry, M.  et al.
(2010)  J.Med.Chem.  53 : 1086 - 1097

PubMed: 20050669
DOI: 10.1021/jm901284w

Reaction

Chain : A
UniProt : P48736 (PK3CG_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) 2.7.1.137 PubMed:11277933, PubMed:16123124
left-to-right PubMed:11277933
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+) 2.7.1.153 PubMed:15135396, PubMed:16123124, PubMed:31554793
left-to-right PubMed:15135396
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4-bisphosphate) + ADP + H(+) 2.7.1.154 PubMed:16123124
left-to-right
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12502714, PubMed:16094730
left-to-right PubMed:12502714