Brand  (β version)

PDB ID: 3KXZ

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Ligands
Code Name Style Show Link
925 3-[7-[(3-hydroxyphenyl)amino]pyrazolo[1,5-a]pyrimidin-2-yl]-N-(1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-yl)benzamide PoSSuM
CA Calcium ion PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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PTR O-phosphotyrosine
Glycosylation
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Modification
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Structure summary

Code : 3KXZ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The complex crystal structure of LCK with a probe molecule w259
Release Data : 2010-06-23
Compound :
mol_id molecule chains synonym
1 Proto-oncogene tyrosine-protein kinase LCK A Lymphocyte cell-specific protein-tyrosine kinase, p56-LCK, LSK, T cell-specific protein-tyrosine kinase
ec: 2.7.10.2
fragment: LCK Ligand Binding Domain, Kinase domain
other_details: unknown polymer
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Baculoviridae  (taxid:10442)
gene: LCK
expression_system_strain: Spodoptera frugiperda sf21
expression_system_cell_line: E. Coli
expression_system_vector_type: PLASMID
expression_system_plasmid: pBacPAK
Authors : Xu, Z.B., Moy, F.J., Kelleher, K., Mosyak, L., Protein Structure Factory (PSF)
Keywords : LCK, Acetylation, ATP-binding, Cell membrane, Chromosomal rearrangement, Cytoplasm, Disease mutation, Host-virus interaction, Kinase, Lipoprotein, Membrane, Myristate, Nucleotide-binding, Palmitate, Phosphoprotein, Polymorphism, Proto-oncogene, Transferase, Tyrosine-protein kinase, Structural Genomics, Protein Structure Factory, PSF
Exp. method : X-RAY DIFFRACTION ( 2.37 Å )
Citation :

Novel synthesis and structural characterization of a high-affinity paramagnetic kinase probe for the identification of non-ATP site binders by nuclear magnetic resonance.

Moy, F.J.,Lee, A.,Gavrin, L.K.  et al.
(2010)  J.Med.Chem.  53 : 1238 - 1249

PubMed: 20038108
DOI: 10.1021/jm901525b

Reaction

Chain : A
UniProt : P06239 (LCK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10028
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