Het-PDB Navi2 (PDB: 3KVX)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
FMY	N-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)aniline				PoSSuM

Non-standard Residues
Code	Name	Show
OCY	Hydroxyethylcysteine

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 3KVX

Code :

3KVX PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

JNK3 bound to aminopyrimidine inhibitor, SR-3562

Release Data :

2009-12-22

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 10	A	Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
	ec: 2.7.11.24 fragment: residues 39-402

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: MAPK10, JNK3, JNK3A, PRKM10 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pDEST14

Authors :

Habel, J.E., Laughlin, J.D., LoGrasso, P.

Keywords :

JNK3, MAPK10, inhibitor, ATP-binding, Epilepsy, Kinase, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Kamenecka, T.,Jiang, R.,Song, X. et al.
(2010) J.Med.Chem. 53 : 419 - 431

Chain :

UniProt :

P53779 (MK10_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.24	-
	-	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.24	-
	-	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:10715136	-

PDB ID: 3KVX