Het-PDB Navi2 (PDB: 3KVI)

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Ligands
Code	Name		Style	Show	Link
FAH	Fluoroacetic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3KVI

Code :

3KVI PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thioesterase FlK - T42A mutant in complex with fluoro-acetate

Release Data :

2010-04-28

Compound :

mol_id	molecule	chains
1	Fluoroacetyl-CoA thioesterase FlK	A,B
	ec: 3.-.-.- fragment: FlK mutation: T42A

Source :

mol_id	organism_scientific	expression_system
1	Streptomyces cattleya (taxid:29303)	Escherichia coli (taxid:469008)
	gene: flK, fluoroacetyl-CoA thioesterase FlK expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid expression_system_plasmid: pET28a

Authors :

Dias, M.V.B., Huang, F., Chirgadze, D.Y., Tosin, M., Spiteller, D., Valentine, E.F., Leadlay, P.F., Spencer, J.B., Blundell, T.L.

Keywords :

fluoroacetyl-CoA thioesterase FlK, thioesterase, hot-dog folding, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.76 Å )

Citation :

Structural basis for the activity and substrate specificity of fluoroacetyl-CoA thioesterase FlK.

Dias, M.V.,Huang, F.,Chirgadze, D.Y. et al.
(2010) J.Biol.Chem. 285 : 22495 - 22504

Chain :

A, B

UniProt :

Q1EMV2 (FLK_STRCT)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)	3.1.2.29	PubMed:16720268, PubMed:20836570
fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+)	-	PubMed:16720268, PubMed:20836570

PDB ID: 3KVI