Brand  (β version)

PDB ID: 3KTU

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
Non-standard Residues
Code Name Show
FDG 2-amino-9-(2-deoxy-2-fluoro-5-O-phosphono-beta-D-arabinofuranosyl)-7,9-dihydro-1h-purine-6,8-dione
Glycosylation
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Structure summary

Code : 3KTU   PDBj   RCSB PDB   PDBe
Header : HYDROLASE,LYASE/DNA
Title : Structure of human 8-oxoGuanine Glycosylase 1 bound to fluorninated oxoG-containing DNA
Release Data : 2010-07-14
Compound :
mol_id molecule chains synonym
1 N-glycosylase/DNA lyase A 8-oxoguanine DNA glycosylase, DNA-(apurinic or apyrimidinic site) lyase
ec: 3.2.2.-, 4.2.99.18
fragment: sequence database residues 12-325
mol_id molecule chains
2 DNA (5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*C)-3') B
mol_id molecule chains
3 DNA (5'-D(*GP*TP*CP*CP*AP*(FDG)P*GP*TP*CP*TP*AP*C)-3') C
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:469008)
gene: MMH, MUTM, OGG1, OGH1
expression_system_strain: BL21(DE3)PLYSS
expression_system_vector_type: plasmid
expression_system_plasmid: pET30a
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
other_details: SYNTHETIC DNA
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
other_details: SYNTHETIC DNA
Authors : Verdine, G.L., Lee, S.M.
Keywords : 8-oxoGuanine, 2'-fluoro-8-oxoGuanine, protein-DNA complex, DNA glycosylase, Base Excsion Repair, DNA damage, DNA repair, HYDROLASE, LYASE-DNA complex
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Structural investigation of hOGG1 bound to a fluorinated oxoG analog

Verdine, G.L.,Lee, S.M.
to be published 

A Catalytic Checkpoint in Base Excision by the Human 8-Oxoguanine DNA Glycosylase hOGG1

Verdine, G.L.,Crenshaw, C.M.,Oo, K.S.  et al.
to be published 

Reaction

Chain : A
UniProt : O15527 (OGG1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'- deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho- 2'-deoxyribonucleoside-DNA + H(+) 4.2.99.18 -
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