Brand  (β version)

PDB ID: 3KRX

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Ligands
Code Name Style Show Link
BA1 Balanol PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
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CMT O-methylcysteine
Glycosylation
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Structure summary

Code : 3KRX   PDBj   RCSB PDB   PDBe
Header : PROTEIN BINDING
Title : Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)
Release Data : 2010-02-16
Compound :
mol_id molecule chains synonym
1 Beta-adrenergic receptor kinase 1 A Beta-ARK-1, G-protein coupled receptor kinase 2
ec: 2.7.11.15
mol_id molecule chains synonym
2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 B Transducin beta chain 1
mol_id molecule chains synonym
3 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 G G gamma-I
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: ADRBK1, BARK, BARK1, GRK2
mol_id organism_scientific organism_common expression_system
2 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow UNIDENTIFIED BACULOVIRUS  (taxid:10469)
gene: GNB1
expression_system_cell_line: Hi-5
mol_id organism_scientific organism_common expression_system
3 Bos taurus  (taxid:9913) Bovine,cow,domestic cattle,domestic cow UNIDENTIFIED BACULOVIRUS  (taxid:10469)
gene: GNG2
expression_system_cell_line: Hi-5
Authors : Tesmer, J.J.G., Tesmer, V.M.
Keywords : RGS HOMOLOGY DOMAIN, ATP-binding, Phosphoprotein, Serine/threonine-protein kinase, Transferase, Transducer, WD repeat, Cell membrane, Lipoprotein, Membrane, Methylation, Prenylation, PROTEIN BINDING
Exp. method : X-RAY DIFFRACTION ( 3.10 Å )
Citation :

Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.

Tesmer, J.J.,Tesmer, V.M.,Lodowski, D.T.  et al.
(2010)  J.Med.Chem.  53 : 1867 - 1870

PubMed: 20128603
DOI: 10.1021/jm9017515

Reaction

Chain : A
UniProt : P25098 (ARBK1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]- phosphate + ADP + H(+) 2.7.11.15 PubMed:19715378
left-to-right
Chain : B
UniProt : P62871 (GBB1_BOVIN)
Reaction : -
Chain : G
UniProt : P63212 (GBG2_BOVIN)
Reaction : -