Brand  (β version)

PDB ID: 3KRD

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Ligands
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HXD (3r)-3-hydroxydodecanoic acid PoSSuM
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Glycosylation
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Structure summary

Code : 3KRD   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with Fellutamide B
Release Data : 2010-09-29
Compound :
mol_id molecule chains synonym
1 Proteasome subunit alpha A,B,D,F,I,K,M,O,Q,S,U,W,Y,1 20S proteasome alpha subunit,Proteasome core protein PrcA
fragment: 20S proteasome alpha subunit
mol_id molecule chains synonym
2 Proteasome subunit beta C,E,G,H,J,L,N,P,R,T,V,X,Z,2 20S proteasome beta subunit,Proteasome core protein PrcB
ec: 3.4.25.1
fragment: 20S proteasome beta subunit
mol_id molecule chains
3 Fellutamide B a,b,c,d,e,f,g,h,i,j,k,l,m,n
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
strain: H37Rv
gene: prcA, MRA_2124
expression_system_strain: Bl21(de3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pACYCDuet
mol_id organism_scientific expression_system
2 Mycobacterium tuberculosis  (taxid:1773) Escherichia coli  (taxid:562)
strain: H37Rv
gene: prcB, MRA_2125
expression_system_strain: Bl21(de3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pACYCDuet
mol_id organism_scientific
3 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Li, D., Li, H.
Keywords : Binding Sites, Mycobacterium tuberculosis, Protein Subunits, Substrate Specificity, Hydrolase, Proteasome, Fellutamide B, inhibition, Protease, Threonine protease, Virulence, Autocatalytic cleavage, Zymogen
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome.

Lin, G.,Li, D.,Chidawanyika, T.  et al.
(2010)  Arch.Biochem.Biophys.  501 : 214 - 220

PubMed: 20558127
DOI: 10.1016/j.abb.2010.06.009

Reaction

Chain : A, B, D, F, I, K, M, O, Q, S, U, W, Y, 1
UniProt : A5U4D5 (PSA_MYCTA)
Reaction : -
Chain : C, E, G, H, J, L, N, P, R, T, V, X, Z, 2
UniProt : A5U4D6 (PSB_MYCTA)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 HAMAP-Rule:MF_02113
-