Het-PDB Navi2 (PDB: 3KM8)

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Ligands
Code	Name		Style	Show	Link
9DI	9-deazainosine				PoSSuM
ZN	Zinc ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3KM8

Code :

3KM8 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structuore of adenosine deaminase from mus musculus complexed with 9-deazainosine

Release Data :

2010-10-20

Compound :

mol_id	molecule	chains	synonym
1	Adenosine deaminase	A,B	Adenosine aminohydrolase
	ec: 3.5.4.4 mutation: E217Q, Y240E

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Mus musculus (taxid:10090)	Mouse	Escherichia coli (taxid:562)
	gene: Ada expression_system_strain: DE3 expression_system_vector_type: PLASMID expression_system_plasmid: pET28a

Authors :

Fan, X., Gao, Y.

Keywords :

HYDROLASE, CYCLICAMIDINES, Metal-binding, Nucleotide metabolism

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

The Catalytic Mechanism of Adenosine Deaminase from Mouse: An Experimental and Theoretical Study

Wu, X.,Fan, X.,Gao, Y. et al.
To be Published

Chain :

A, B

UniProt :

P03958 (ADA_MOUSE)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
adenosine + H(+) + H2O = inosine + NH4(+)	3.5.4.4	PubMed:10720488, PubMed:8634299, PubMed:8672487, PubMed:8942668, PubMed:9272950
adenosine + H(+) + H2O = inosine + NH4(+)	left-to-right	PubMed:10720488
2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)	3.5.4.4	PubMed:10720488
2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)	left-to-right	PubMed:10720488

PDB ID: 3KM8