Brand  (β version)

PDB ID: 3KFY

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
JZM 5-[(4-chlorophenyl)sulfanyl]quinazoline-2,4-diamine PoSSuM
NDP Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate PoSSuM
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Structure summary

Code : 3KFY   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR
Release Data : 2010-12-08
Compound :
mol_id molecule chains
1 Dihydrofolate reductase A
ec: 1.5.1.3
Source :
mol_id organism_scientific
1 Escherichia coli  (taxid:83333)
strain: K12
Authors : Collins, E.J., Lee, A.L., Carroll, M.J., Gromova, A.V., Miller, K.R., Singleton, S.F.
Keywords : small molecule inhibitor, dynamics, Antibiotic resistance, Methotrexate resistance, NADP, One-carbon metabolism, Oxidoreductase, Trimethoprim resistance
Exp. method : X-RAY DIFFRACTION ( 2.08 Å )
Citation :

Dynamic switching and partial occupancies of a small molecule inhibitor complex of DHFR

Collins, E.J.,Lee, A.L.,Carroll, M.J.  et al.
To be Published 

Reaction

Chain : A
UniProt : P0ABQ4 (DYR_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH 1.5.1.3 PROSITE- ProRule:PRU00660, PubMed:16510443
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