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Ligands
Code Name Style Show Link
CL Chloride ion
F2C 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid
NA Sodium ion
Non-standard Residues
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Glycosylation
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Code : 3K7F   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure Analysis of a Phenhexyl/Oxazole/Carboxypyridine alpha-Ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase'
Release Data : 2009-12-01
Compound :
mol_id molecule chains synonym
1 Fatty-acid amide hydrolase 1 A,B Oleamide hydrolase 1, Anandamide amidohydrolase 1
ec: 3.5.1.-
fragment: deltaTM-FAAH
mutation: L192F, F194Y, A377T, S435N, I491V, V495M
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Rat Escherichia coli  (taxid:562)
gene: Faah, faah-1, Faah1
expression_system_strain: BL21
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28a
Authors : Mileni, M., Stevens, R.C., Boger, D.L.
Keywords : protein-inhibitor complex, FAAH, oxazole, Hydrolase, Membrane, Transmembrane
Exp. method : X-RAY DIFFRACTION ( 1.950 Å )
Citation :

X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.

Mileni, M.,Garfunkle, J.,Ezzili, C.  et al.
(2010)  J.Med.Chem.  53 : 230 - 240

PubMed: 19924997
DOI: 10.1021/jm9012196

Chain : A, B
UniProt : P97612 (FAAH1_RAT)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine 3.5.1.99 PubMed:10526230, PubMed:11128635, PubMed:17649977, PubMed:9122178, PubMed:9299394
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(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+) 3.5.1.99 PubMed:10526230, PubMed:11128635, PubMed:9122178, PubMed:9299394, PubMed:9790682
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2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) - PubMed:10526230, PubMed:15533037, PubMed:17649977
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(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)- octadecatrienoate + NH4(+) - PubMed:11128635
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(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)- eicosatetraenoate + NH4(+) - PubMed:11128635, PubMed:9299394
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(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+) - PubMed:11128635
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(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+) - PubMed:11128635
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(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)- eicosatrienoate + NH4(+) - PubMed:11128635
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(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)- eicosatrienoate + NH4(+) - PubMed:11128635
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(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+) - PubMed:11128635
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(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+) - PubMed:11128635
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H2O + tetradecamide = NH4(+) + tetradecanoate - PubMed:9122178
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H2O + N-(9Z-octadecenoyl) ethanolamine = (9Z)-octadecenoate + ethanolamine - PubMed:15533037
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H2O + N-(9Z-octadecenoyl)-taurine = (9Z)-octadecenoate + taurine - PubMed:15533037
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1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + methanol - PubMed:9299394
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(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+) - PubMed:11128635
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H2O + N-(9Z-hexadecenoyl) ethanolamine = (9Z)-hexadecenoate + ethanolamine - UniProtKB:O08914
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H2O + N-octadecanoyl ethanolamine = ethanolamine + octadecanoate - UniProtKB:O08914
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H2O + N-docosanoyl-ethanolamine = docosanoate + ethanolamine - UniProtKB:O08914
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H2O + N-tetracosanoyl-taurine = taurine + tetracosanoate - UniProtKB:O08914
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H2O + N-(15Z-tetracosenoyl)-ethanolamine = (15Z)- tetracosenoate + ethanolamine - UniProtKB:O08914
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H2O + N-docosanoyl-taurine = docosanoate + taurine - UniProtKB:O08914
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H2O + N-(15Z-tetracosenoyl)-taurine = (15Z)-tetracosenoate + taurine - UniProtKB:O08914
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H2O + N-tricosanoyl-taurine = taurine + tricosanoate - UniProtKB:O08914
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(9Z)-octadecenoate + glycine = H2O + N-(9Z- octadecenoyl)glycine - UniProtKB:O08914
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H2O + N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine - UniProtKB:O08914
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H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine - UniProtKB:O08914
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