Brand  (β version)

PDB ID: 3K3I

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Ligands
Code Name Style Show Link
I46 2-fluoro-4-[4-(4-fluorophenyl)-1h-pyrazol-3-yl]pyridine PoSSuM
JZJ (3s)-3-[4-(4-bromophenyl)-1h-imidazol-2-yl]-1,2,3,4-tetrahydroisoquinoline PoSSuM
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Structure summary

Code : 3K3I   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : p38alpha bound to novel DGF-out compound PF-00215955
Release Data : 2009-11-17
Compound :
mol_id molecule chains synonym
1 Mitogen-activated protein kinase 14 A Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
ec: 2.7.11.24
fragment: UNP residues 5-352
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, P38
Authors : Kazmirski, S.L., DiNitto, J.P.
Keywords : P38 Kinase, Alternative splicing, ATP-binding, Cytoplasm, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.

Tecle, H.,Feru, F.,Liu, H.  et al.
(2009)  Chem.Biol.Drug Des.  74 : 547 - 559

PubMed: 19843080
DOI: 10.1111/j.1747-0285.2009.00884.x

Reaction

Chain : A
UniProt : Q16539 (MK14_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.24 PubMed:11010976, PubMed:35857590
left-to-right PubMed:11010976, PubMed:35857590