Brand  (β version)

PDB ID: 3JZF

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Ligands
Code Name Style Show Link
CO3 Carbonate ion PoSSuM
JZK 2-[(2-chlorobenzyl)amino]-1-(cyclohexylmethyl)-1h-benzimidazole-5-carboxamide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3JZF   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazoles series
Release Data : 2009-11-03
Compound :
mol_id molecule chains synonym
1 Biotin carboxylase A,B Acetyl-CoA carboxylase subunit A, ACC
ec: 6.3.4.14, 6.4.1.2
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:83333) Escherichia coli  (taxid:562)
strain: K12
gene: accC, fabG, b3256, JW3224
Authors : Orth, P.
Keywords : Biotin carboxylase, AccC, Acetyl coenzyme-A carboxylase, ACCase, ATP-binding, Biotin, Fatty acid biosynthesis, Ligase, Lipid synthesis, Nucleotide-binding
Exp. method : X-RAY DIFFRACTION ( 2.13 Å )
Citation :

Discovery and optimization of antibacterial AccC inhibitors.

Cheng, C.C.,Shipps, G.W.,Yang, Z.  et al.
(2009)  Bioorg.Med.Chem.Lett.  19 : 6507 - 6514

PubMed: 19875284
DOI: 10.1016/j.bmcl.2009.10.057

Reaction

Chain : A, B
UniProt : P24182 (ACCC_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate 6.3.4.14 PubMed:16793549, PubMed:19213731
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