Brand  (β version)

color scheme of protein:


interaction residue:

chain: Hide other chain(s)

Code Name Link
ZN Zinc ion
ACT Acetate ion
CAD Cacodylic acid
GOL Glycerol
H4B 5,6,7,8-tetrahydrobiopterin
HEM Protoporphyrin ix containing Fe
JI5 N-{(3r,4r)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine
Code : 3JWX
Title : Structure of endothelial nitric oxide synthase heme domain complexed with N1-[(3'R,4'R)-4'-((6"-amino-4"-methylpyridin-2"-yl)methyl)pyrrolidin-3'-yl]-N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride
Release Data : 2010-05-05
Compound :
mol_id molecule chains synonym
1 Nitric oxide synthase, endothelial A,B Endothelial NOS, eNOS, EC-NOS, NOS type III, NOSIII, Constitutive NOS, cNOS
fragment: Residues 39-482
Source :
mol_id organism_scientific organism_common expression_system
1 Bos taurus  (taxid:9913) Bovine Escherichia coli  (taxid:562)
gene: NOS3
expression_system_strain: BL21 (DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pCWori
Authors : Delker, S.L., Li, H., Poulos, T.L.
Keywords : heme enzyme, substrate inhibitor, Oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model.

Delker, S.L.,Ji, H.,Li, H.  et al.
(2010)  J.Am.Chem.Soc.  132 : 5437 - 5442

PubMed: 20337441
DOI: 10.1021/ja910228a

Chain : A, B
UniProt : P29473 (NOS3_BOVIN)
Reaction : 2 L-arginine + 3 NADPH + 4 O(2) = 2 L- citrulline + 2 nitric oxide + 3 NADP(+) + 4 H(2)O.