PDB ID: 3JSW
Hetero Atom Contents
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Color scheme of protein:
Code | Name | Style | Show | Link | |
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ZN | Zinc ion | PoSSuM | |||
MG | Magnesium ion | PoSSuM | |||
JAR | 6-[(3s,4s)-1-benzyl-4-methylpyrrolidin-3-yl]-1-(1-methylethyl)-1,5-dihydro-4h-pyrazolo[3,4-D]pyrimidin-4-one | PoSSuM |
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Download interaction data: 3JSW
Structure summary
Code : | 3JSW PDBj RCSB PDB PDBe | ||||||||||||
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Header : | HYDROLASE | ||||||||||||
Title : | Human PDE9 in complex with selective inhibitor | ||||||||||||
Release Data : | 2009-12-01 | ||||||||||||
Compound : |
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Source : |
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Authors : | Liu, S. | ||||||||||||
Keywords : | phosphodiesterase, cGMP, Hydrolase, Manganese, Metal-binding, Phosphoprotein | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.30 Å ) | ||||||||||||
Citation : |
Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy.
Verhoest, P.R.,Proulx-Lafrance, C.,Corman, M.
et al.
PubMed: 19919087 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | O76083 (PDE9A_HUMAN) | ||||||||
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