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Ligands
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IVM (2ae,4e,5'S,6s,6'R,7s,8e,11r,13r,15s,17ar,20r,20ar,20bs)-6'-[(2s)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2h,7h-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
: Polysaccharide
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Code : 3JAF   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state
Release Data : 2015-09-09
Compound :
mol_id molecule chains synonym
1 Glycine receptor subunit alphaZ1 A,B,C,D,E alpha1 glycine receptor
Source :
mol_id organism_scientific organism_common expression_system
1 Danio rerio  (taxid:7955) Zebra fish Spodoptera frugiperda  (taxid:7108)
gene: glra1
expression_system_common: Fall armyworm
expression_system_cell_line: sf9
expression_system_vector_type: baculovirus
Authors : Du, J., Lu, W., Wu, S.P., Cheng, Y.F., Gouaux, E.
Keywords : cys loop receptor, alpha-1 glycine receptor, glycine, ivermectin, SIGNALING PROTEIN
Exp. method : ELECTRON MICROSCOPY ( 3.8 Å )
Citation :

Glycine receptor mechanism elucidated by electron cryo-microscopy.

Du, J.,Lu, W.,Wu, S.  et al.
(2015)  Nature  526 : 224 - 229

PubMed: 26344198
DOI: 10.1038/nature14853