Het-PDB Navi2 (PDB: 3IXH)

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Download interaction data: 3IXH

Code :

3IXH PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

X-ray crystal structure of the extended-spectrum AmpC Y221G mutant beta-lactamase in complex with cefotaxime at 2.3 Angstrom resolution

Release Data :

2010-02-16

Compound :

mol_id	molecule	chains	synonym
1	Beta-lactamase	B,A	Cephalosporinase
	ec: 3.5.2.6 mutation: Y221G

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:83333)	Escherichia coli (taxid:562)
	strain: K12 gene: ampA, ampC, b4150, JW4111 expression_system_strain: JM109 expression_system_vector_type: plasmid expression_system_plasmid: pOGO295

Authors :

Shoichet, B.K., Thomas, V.L.

Keywords :

serine hydrolase, beta-lactamase, cephalosporinase, extended-spectrum antibiotic resistance, Antibiotic resistance, Hydrolase

Exp. method :

X-RAY DIFFRACTION ( 2.300 Å )

Citation :

Structural bases for stability-function tradeoffs in antibiotic resistance.

Thomas, V.L.,McReynolds, A.C.,Shoichet, B.K.
(2010) J.Mol.Biol. 396 : 47 - 59

Chain :

B, A

UniProt :

P00811 (AMPC_ECOLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE-ProRule:PRU10102, PubMed:12323371, PubMed:3264154, PubMed:3264155, PubMed:6998377
a beta-lactam + H2O = a substituted beta-amino acid	-

PDB ID: 3IXH