Het-PDB Navi2 (PDB: 3ISG)

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Ligands
Code	Name		Style	Show	Link
DRW	(2s,3r,4s)-2-[(2s,3r)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3s,5s)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2h-pyrrole-5-carboxylic acid				PoSSuM

Non-standard Residues
Code	Name	Show
KCX	Lysine nz-carboxylic acid

Glycosylation
Code	Name	Emphasize

Modification
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Download interaction data: 3ISG

Code :

3ISG PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Structure of the class D beta-lactamase OXA-1 in complex with doripenem

Release Data :

2009-12-01

Compound :

mol_id	molecule	chains	synonym
1	Beta-lactamase OXA-1	A,B	Penicillinase
	ec: 3.5.2.6 fragment: UNP residues 26-276

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:562)
	gene: bla, oxa1 expression_system_strain: BL21 expression_system_vector_type: plasmid expression_system_plasmid: pET12A

Authors :

Powers, R.A.

Keywords :

hydrolase, lysine carboxylation, Antibiotic resistance

Exp. method :

X-RAY DIFFRACTION ( 1.400 Å )

Citation :

The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem.

Schneider, K.D.,Karpen, M.E.,Bonomo, R.A. et al.
(2009) Biochemistry 48 : 11840 - 11847

Chain :

A, B

UniProt :

P13661 (BLO1_ECOLX)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE- ProRule:PRU10103
a beta-lactam + H2O = a substituted beta-amino acid	-	PROSITE- ProRule:PRU10103

PDB ID: 3ISG