Brand  (β version)

PDB ID: 3IQV

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
FSC Fusicoccin PoSSuM
MG Magnesium ion PoSSuM
Non-standard Residues
Code Name Show
CSO S-hydroxycysteine
SEP Phosphoserine
Glycosylation
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Structure summary

Code : 3IQV   PDBj   RCSB PDB   PDBe
Header : PROTEIN BINDING, SIGNALING PROTEIN
Title : Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator Fusicoccin
Release Data : 2010-09-01
Compound :
mol_id molecule chains synonym
1 14-3-3 protein sigma A Stratifin, Epithelial cell marker protein 1
fragment: UNP residues 1-231
mol_id molecule chains synonym
2 6-mer peptide from RAF proto-oncogene serine/threonine-protein kinase P C-RAF, cRaf, Raf-1
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
mol_id organism_scientific
2
synthetic: yes
other_details: The peptide was chemically synthesized. The sequence of the peptide is naturally found in Homo sapiens (human)
Authors : Ottmann, C., Weyand, M.
Keywords : SIGNAL TRANSDUCTION, Nucleus, Phosphoprotein, Secreted, PROTEIN BINDING, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.20 Å )
Citation :

Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.

Molzan, M.,Schumacher, B.,Ottmann, C.  et al.
(2010)  Mol.Cell.Biol.  30 : 4698 - 4711

PubMed: 20679480
DOI: 10.1128/MCB.01636-09

Reaction

Chain : A
UniProt : P31947 (1433S_HUMAN)
Reaction : -
Chain : P
UniProt : P04049 (RAF1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:17603483
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:17603483
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