Brand  (β version)

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Ligands
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DRW (2s,3r,4s)-2-[(2s,3r)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-4-({(3s,5s)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-3,4-dihydro-2h-pyrrole-5-carboxylic acid
PO4 Phosphate ion
Non-standard Residues
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Code : 3IQA   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Crystal Structure of BlaC covalently bound with Doripenem
Release Data : 2010-04-14
Compound :
mol_id molecule chains synonym
1 Beta-lactamase A Penicillinase
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:83332) Escherichia coli  (taxid:562)
strain: H37Rv
gene: blaA, blaC, MT2128, MTCY49.07c, Rv2068c
expression_system_strain: Rosetta2
expression_system_vector_type: plasmid
expression_system_plasmid: pET28a
Authors : Tremblay, L.W., Blanchard, J.S.
Keywords : penicillin binding protein, beta-lactam covalent adduct, Antibiotic resistance, Cell membrane, Hydrolase, Lipoprotein, Membrane, Palmitate, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.

Tremblay, L.W.,Fan, F.,Blanchard, J.S.
(2010)  Biochemistry  49 : 3766 - 3773

PubMed: 20353175
DOI: 10.1021/bi100232q

Chain : A
UniProt : P0C5C1 (multiple entry names are found)
Reaction : -