Het-PDB Navi2 (PDB: 3IPQ)

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Ligands
Code	Name		Style	Show	Link
965	[3-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid				PoSSuM
SO4	Sulfate ion				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 3IPQ

Code :

3IPQ PDBj RCSB PDB PDBe

Header :

TRANSCRIPTION

Title :

X-ray structure of GW3965 synthetic agonist bound to the LXR-alpha

Release Data :

2010-06-02

Compound :

mol_id	molecule	chains	synonym
1	Oxysterols receptor LXR-alpha	A	Liver X receptor alpha, Nuclear orphan receptor LXR-alpha, Nuclear receptor subfamily 1 group H member 3
	fragment: Ligand binding domain: UNP residues 182-447

mol_id	molecule	chains	synonym
2	Nuclear receptor coactivator 1	B	NCoA-1, Steroid receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52
	ec: 2.3.1.48 fragment: Steroid receptor co-activator 1: UNP residues 676-700

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: LXRA, NR1H3 expression_system_strain: DH10-T1r expression_system_vector_type: plasmid expression_system_plasmid: pSX29

mol_id	organism_scientific
2
	synthetic: yes other_details: SRC-1 peptide from MilliQ with the sequence based on UniProt entry Q15788 (NCOA1_HUMAN), residues 676-700.

Authors :

Fradera, X., Vu, D., Nimz, O., Skene, R., Hosfield, D., Wijnands, R., Cooke, A.J., Haunso, A., King, A., Bennet, D.J., McGuire, R., Uitdehaag, J.C.M.

Keywords :

Nuclear receptor, LXR homodimer, LXR signaling, Alternative splicing, DNA-binding, Metal-binding, Nucleus, Polymorphism, Receptor, Transcription, Transcription regulation, Zinc, Zinc-finger, Activator, Acyltransferase, Chromosomal rearrangement, Isopeptide bond, Phosphoprotein, Proto-oncogene, Transferase, Ubl conjugation

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling.

Fradera, X.,Vu, D.,Nimz, O. et al.
(2010) J.Mol.Biol. 399 : 120 - 132

PubMed: 20382159
DOI: 10.1016/j.jmb.2010.04.005

Chain :	A
UniProt :	Q13133 (NR1H3_HUMAN)
Reaction :	-

Chain :

UniProt :

Q15788 (NCOA1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein]	2.3.1.48	-
	-	-

PDB ID: 3IPQ

Hetero Atom Contents

Structure summary

Reaction