Brand  (β version)

PDB ID: 3IMV

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Ligands
Code Name Style Show Link
IW5 4-[(E)-2-(4-aminophenyl)ethenyl]-2,6-dibromoaniline PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 3IMV   PDBj   RCSB PDB   PDBe
Header : HORMONE
Title : Transthyretin in complex with (E)-4-(4-aminostyryl)-2,6-dibromoaniline
Release Data : 2010-01-12
Compound :
mol_id molecule chains synonym
1 Transthyretin A,B Prealbumin, TBPA, TTR, ATTR
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: TTR, PALB
expression_system_strain: Epicuran gold
expression_system_vector_type: Plasmid
expression_system_plasmid: pmmHA
Authors : Connelly, S., Wilson, I.A.
Keywords : Hormone, Growth Factor, Amyloid, Disease mutation, Gamma-carboxyglutamic acid, Glycoprotein, Polymorphism, Polyneuropathy, Retinol-binding, Secreted, Thyroid hormone, Transport, Vitamin A
Exp. method : X-RAY DIFFRACTION ( 1.47 Å )
Citation :

A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.

Choi, S.,Reixach, N.,Connelly, S.  et al.
(2010)  J.Am.Chem.Soc.  132 : 1359 - 1370

PubMed: 20043671
DOI: 10.1021/ja908562q

Reaction

Chain : A, B
UniProt : P02766 (TTHY_HUMAN)
Reaction : -