PDB ID: 3IKA
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Structure summary
Code : | 3IKA PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSFERASE | ||||||||||||
Title : | Crystal Structure of EGFR 696-1022 T790M Mutant Covalently Binding to WZ4002 | ||||||||||||
Release Data : | 2010-01-12 | ||||||||||||
Compound : |
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Source : |
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Authors : | Yun, C.-H., Eck, M.J. | ||||||||||||
Keywords : | EGFR, T790M, WZ4002, WZ-4002, Alternative splicing, ATP-binding, Cell membrane, Disease mutation, Disulfide bond, Glycoprotein, Isopeptide bond, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Receptor, Secreted, Transferase, Transmembrane, Tumor suppressor, Tyrosine-protein kinase, Ubl conjugation | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.90 Å ) | ||||||||||||
Citation : |
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Zhou, W.,Ercan, D.,Chen, L.
et al.
PubMed: 20033049 |
Reaction
Chain : | A, B | ||||||||
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UniProt : | P00533 (EGFR_HUMAN) | ||||||||
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