Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CA Calcium ion
ZN Zinc ion
099 (2r)-N~4~-hydroxy-2-(3-hydroxybenzyl)-N~1~-[(1s,2r)-2-hydroxy-2,3-dihydro-1h-inden-1-yl]butanediamide
Code : 3HYG
Header : HYDROLASE
Title : Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with an Amino-2-indanol compound
Release Data : 2009-07-07
Compound :
mol_id molecule chains synonym
1 A disintegrin and metalloproteinase with thrombospondin motifs 5 A,B ADAMTS-5, ADAM-TS 5, ADAM-TS5, Aggrecanase-2, ADMP-2, A disintegrin and metalloproteinase with thrombospondin motifs 11, ADAMTS-11, ADAM-TS 11
ec: 3.4.24.-
fragment: Catalytic Domain (UNP residues 262 to 480)
mutation: L282K
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ADAMTS-5, ADAMTS11, ADAMTS5, ADMP2
expression_system_strain: MON208
expression_system_vector_type: plasmid
expression_system_plasmid: PPHA79257
Authors : Shieh, H.-S., Williams, J.M., Caspers, N., Mathis, K.J., Tortorella, M.D., Tomasselli, A.
Keywords : alpha/beta structure, central five stranded beta-sheet, Cleavage on pair of basic residues, Disulfide bond, Extracellular matrix, Glycoprotein, Hydrolase, Metal-binding, Metalloprotease, Polymorphism, Protease, Secreted, Zinc, Zymogen
Exp. method : X-RAY DIFFRACTION ( 1.40 Å )
Citation :

Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors

Tortorella, M.D.,Tomasselli, A.G.,Mathis, K.J.  et al.
(2009)  J.Biol.Chem.  284 : 24185 - 24191

PubMed: 19586907
DOI: 10.1074/jbc.M109.029116

Chain : A, B
UniProt : Q9UNA0 (ATS5_HUMAN)
Reaction : Cleaves aggrecan at the 392-Glu-|-Ala-393 site.