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Ligands
Code Name Style Show Link
HYE (2r,3s,4r)-2-[(S)-(1s)-cyclohex-2-en-1-yl(hydroxy)methyl]-3-hydroxy-4-(2-hydroxyethyl)-3-methyl-5-oxopyrrolidine-2-carbaldehyde
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
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Code : 3HYE   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of 20S proteasome in complex with hydroxylated salinosporamide
Release Data : 2009-09-15
Compound :
mol_id molecule chains synonym
1 Proteasome component Y7 A,O Macropain subunit Y7, Proteinase YSCE subunit 7, Multicatalytic endopeptidase complex subunit Y7
ec: 3.4.25.1
mol_id molecule chains synonym
2 Proteasome component Y13 B,P Macropain subunit Y13, Proteinase YSCE subunit 13, Multicatalytic endopeptidase complex subunit Y13
ec: 3.4.25.1
mol_id molecule chains synonym
3 Proteasome component PRE6 C,Q Macropain subunit PRE6, Proteinase YSCE subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6
ec: 3.4.25.1
mol_id molecule chains synonym
4 Proteasome component PUP2 D,R Macropain subunit PUP2, Proteinase YSCE subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2
ec: 3.4.25.1
mol_id molecule chains synonym
5 Proteasome component PRE5 E,S Macropain subunit PRE5, Proteinase YSCE subunit PRE5, Multicatalytic endopeptidase complex subunit PRE5
ec: 3.4.25.1
mol_id molecule chains synonym
6 Proteasome component C1 F,T Macropain subunit C1, Proteinase YSCE subunit 1, Multicatalytic endopeptidase complex subunit C1
ec: 3.4.25.1
mol_id molecule chains synonym
7 Proteasome component C7-alpha G,U Macropain subunit C7-alpha, Proteinase YSCE subunit 7, Multicatalytic endopeptidase complex C7, Proteasome component Y8, SCL1 suppressor protein
ec: 3.4.25.1
mol_id molecule chains synonym
8 Proteasome component PUP1 H,V Macropain subunit PUP1, Proteinase YSCE subunit PUP1, Multicatalytic endopeptidase complex subunit PUP1
ec: 3.4.25.1
mol_id molecule chains synonym
9 Proteasome component PUP3 I,W Macropain subunit PUP3, Multicatalytic endopeptidase complex subunit PUP3
ec: 3.4.25.1
mol_id molecule chains synonym
10 Proteasome component C11 J,X Macropain subunit C11, Proteinase YSCE subunit 11, Multicatalytic endopeptidase complex subunit C11
ec: 3.4.25.1
mol_id molecule chains synonym
11 Proteasome component PRE2 K,Y Macropain subunit PRE2, Proteinase YSCE subunit PRE2, Multicatalytic endopeptidase complex subunit PRE2
ec: 3.4.25.1
mol_id molecule chains synonym
12 Proteasome component C5 L,Z Multicatalytic endopeptidase complex subunit C5
ec: 3.4.25.1
mol_id molecule chains synonym
13 Proteasome component PRE4 M,1 Macropain subunit PRE4, Proteinase YSCE subunit PRE4, Multicatalytic endopeptidase complex subunit PRE4
ec: 3.4.25.1
mol_id molecule chains synonym
14 Proteasome component PRE3 N,2 Macropain subunit PRE3, Proteinase YSCE subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3
ec: 3.4.25.1
Source :
mol_id organism_scientific organism_common
1 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
2 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
3 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
4 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
5 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
6 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
7 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
8 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
9 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
10 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
11 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
12 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
13 Saccharomyces cerevisiae  (taxid:4932) Yeast
mol_id organism_scientific organism_common
14 Saccharomyces cerevisiae  (taxid:4932) Yeast
Authors : Groll, M., Arthur, K.A.M., Macherla, V.R., Manam, R.R., Potts, B.C.
Keywords : Cytoplasm, Hydrolase, Nucleus, Phosphoprotein, Protease, Proteasome, Threonine protease, Isopeptide bond, Ubl conjugation, Zymogen
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition

Groll, M.,McArthur, K.A.,Macherla, V.R.  et al.
(2009)  J.Med.Chem.  52 : 5420 - 5428

PubMed: 19678642
DOI: 10.1021/jm900559x

Chain : A, O
UniProt : P23639 (PSA2_YEAST)
Reaction : -
Chain : B, P
UniProt : P23638 (PSA3_YEAST)
Reaction : -
Chain : C, Q
UniProt : P40303 (PSA4_YEAST)
Reaction : -
Chain : D, R
UniProt : P32379 (PSA5_YEAST)
Reaction : -
Chain : E, S
UniProt : P40302 (PSA6_YEAST)
Reaction : -
Chain : F, T
UniProt : P21242 (PSA7_YEAST)
Reaction : -
Chain : G, U
UniProt : P21243 (PSA1_YEAST)
Reaction : -
Chain : H, V
UniProt : P25043 (PSB2_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-
Chain : I, W
UniProt : P25451 (PSB3_YEAST)
Reaction : -
Chain : J, X
UniProt : P22141 (PSB4_YEAST)
Reaction : -
Chain : K, Y
UniProt : P30656 (PSB5_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-
Chain : L, Z
UniProt : P23724 (PSB6_YEAST)
Reaction : -
Chain : M, 1
UniProt : P30657 (PSB7_YEAST)
Reaction : -
Chain : N, 2
UniProt : P38624 (PSB1_YEAST)
Reaction: EC: Evidence:
Physiological Direction:
Cleavage of peptide bonds with very broad specificity. 3.4.25.1 -
-