Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
CEW (2r)-2-[(1r)-1-({[(2r)-2-amino-2,3-dihydro-1,3-thiazol-4-yl](methoxyimino)acetyl}amino)-2-oxoethyl]-5-methyl-3,6-dihydro-2h-1,3-thiazine-4-carboxylic acid
Code : 3HUM
Header : HYDROLASE/Antibiotics
Title : Crystal structure of Penicillin binding protein 4 from Staphylococcus aureus COL in complex with Cefotaxime
Release Data : 2009-11-10
Compound :
mol_id molecule chains
1 Penicillin-binding protein 4 A,B
ec: 3.4.16.4
mutation: T189S
Source :
mol_id organism_scientific expression_system
1 Staphylococcus aureus  (taxid:93062) Escherichia coli  (taxid:562)
strain: COL
gene: pbp4
expression_system_strain: BL21DE3
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28a
Authors : Navratna, V., Gopal, B.
Keywords : Penicillin binding protein 4, Cefotaxime, beta-lactamase, Serine type D-Ala, D-Ala-carboxypeptidase, Antibiotics, HYDROLASE-Antibiotics complex
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

Molecular basis for the role of Staphylococcus aureus Penicillin Binding Protein 4 in antimicrobial resistance

Navratna, V.,Nadig, S.,Sood, V.  et al.
(2009)  J.Bacteriol. 

PubMed: 19854906
DOI: 10.1128/JB.00822-09

Chain : A, B
UniProt : Q5HI26 (No found in current UniProtKB/SwissProt)
Reaction : -