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Ligands
Code Name Style Show Link
MG Magnesium ion
K Potassium ion
OXL Oxalate ion
ATP Adenosine-5'-triphosphate
FDP 2,6-di-O-phosphono-beta-D-fructofuranose
Non-standard Residues
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Glycosylation
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Code : 3HQP   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK) in complex with ATP, Oxalate and fructose 2,6 bisphosphate
Release Data : 2010-02-16
Compound :
mol_id molecule chains synonym
1 Pyruvate kinase A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P PK
ec: 2.7.1.40
Source :
mol_id organism_scientific expression_system
1 Leishmania mexicana  (taxid:5665) Escherichia coli  (taxid:562)
strain: NHOM/B2/84/BEL46
gene: PYK
expression_system_strain: BL21(DE3)pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pET3A_lmPYK
Authors : Morgan, H.P., Walkinshaw, M.D.
Keywords : TIM BARREL, T-STATE ENZYME, Allosteric enzyme, Glycolysis, Kinase, Magnesium, Metal-binding, Pyruvate, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model

Morgan, H.P.,McNae, I.W.,Nowicki, M.W.  et al.
(2010)  J.Biol.Chem.  285 : 12892 - 12898

PubMed: 20123988
DOI: 10.1074/jbc.M109.079905

Chain : A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
UniProt : Q27686 (KPYK_LEIME)
Reaction: EC: Evidence:
Physiological Direction:
ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate 2.7.1.40 -
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